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Post-doc position in Cell Biology at U. of Crete

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From: "HR-Net News Distribution Manager" <>

Originally From: George Zachos <gzachos at>

Job Vacancy: Postdoctoral Research Scientist

Genetic and molecular analysis of Chk1 functions in the mitotic spindle checkpoint and cytokinesis

Prof George Zachos

Starting date: 1 October 2008. 3-year fixed-term contract. Salary will depend on experience.

The Cell Cycle and Division Laboratory of the Department of Biology, University of Crete is interested in understanding the mechanisms of cell cycle checkpoints triggered by DNA damage, inhibition of DNA replication and spindle poisons (Zachos et al, EMBOJ 22: 713-723, 2003- Zachos et al, Mol. Cell. Biol. 25: 563-574, 2005). Recently, we were the first to show that Chk1 protein kinase, a well-established component of the DNA damage checkpoint, is also required for the mitotic spindle checkpoint (Zachos et al, Dev Cell 12: 247-260, 2007).

We are seeking a highly motivated and dedicated postdoctoral research scientist to further explore this novel role of Chk1 in mitosis by investigating the mechanism by which Chk1 regulates the mitotic kinase Aurora-B, defining a novel role for Chk1 in cytokinesis and determining the mechanism of Chk1 regulation during cell division. Studies will involve standard eukaryotic cell biology approaches, RNAi, confocal and time-lapse microscopy, flow cytometry, mutational and biochemical analysis of protein function.

Applications with CV and names of two referees should be sent to Prof George Zachos, Department of Biology University of Crete, Vassilika Vouton, Heraklion 71409, Crete, Greece, PO Box 2208 or by email to gzachos at

This research project is funded by the Association for International Cancer Research (AICR) project grant award No 08-0525.

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